What are the causes of miscarriages?

        There are many possible causes for miscarriage, including: genetic and hormonal problems; infection and  defects in blood-clotting; uterine problems and cervical weakness. The treatment recommendations for patients with recurrent pregnancy loss are based on the underlying cause of recurrent pregnancy loss. 

Genetic causes – 2% to 4% of miscarriages are associated with a parental balanced structural chromosome rearrangement. These women experience repeated loss of pregnancy. In such a case your doctor may advise chromosomal analysis of both the partners to find the cause. Women older than age 35 have a higher risk of miscarriage than do younger women. This may be due to chromosomal defects in eggs of ageing women.

Defects in the womb (uterus) – Some women may be born with defect in the size and shape of uterus. These are called congenital uterine anomalies and they include small uterus, T shaped uterus etc. Unicornuate, didelphic, and bicornuate uteri have been associated with smaller increases in the risk for loss of pregnancy.

You may have abortions if your uterus is divided by intrauterine adhesions, uterine fibroids or polyps. The uterine septum is the congenital uterine anomaly most closely linked to repeated abortions. Intramural fibroids larger than 5 cm, as well as submucosal fibroids of any size, can cause repeated loss of pregnancy.

Hormone imbalance – An condition called luteal phase defect can risk your pregnancy. Early pregnancy is secured by hormone like Progesterone. If this hormone is deficient then women may experience miscarriages. Often this condition is seen in women with PCOS. Polycystic ovarian syndrome (PCOS) can lead recurrent abortions due to luteal phase defect.

Infections – Infections speculated to play a role in RPL include mycoplasma, ureaplasma, Chlamydia trachomatis, L monocytogenes, and HSV. You must report to the doctor at the earliest if you are experiencing symptoms of urinary or vaginal infections. Apart from local infections any severe infections with fever are also dangerous in pregnancy.

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